Dermo-cosmetics – Histocell Regenerative Medicine

DERMO-COSMETICS

Active ingredients, medical devices and cosmetic products

Development and manufacture of effective products of natural origin for dermo-cosmetic skin and hair treatments.

Histocell presents as an ideal partner for open innovation in dermo-cosmetics.

Specialists in biotechnologies focused on regeneration and oxidative stress control applied to dermo-cosmetics.

OUR KNOW-HOW

Biotechnologies

Histocell has two proprietary technologies

HISTOESSENCE TECHNOLOGY

Technology based on a unique natural blend of sulphated glycosaminoglycans (chondroitin sulphate, heparan sulphate, keratan sulphate and dermatan sulphate) and polydisperse hyaluronic acid.

What do these components bring?

Recreates and regenerates the extracellular matrix
Induces synthesis of collagen and fibronectin
Promotes cell migration

HISTOESSENCE MIMICS THE EXTRACELLULAR MATRIX

Self-controlled industrial purification process providing extracellular matrix at different purities for a family of products (cosmetics - class III medical devices).

REOXCARE TECHNOLOGY

Technology based on an exclusive blend of natural antioxidant active ingredients.

What do these components bring?

LBG (galactomannan): obtained from carob seed flour. Used in traditional medicine as an antioxidant and anti-inflammatory solution.
Ascorbic acid: essential micronutrient for wound healing. Induces collagen synthesis and gives strength and resilience to new tissue.
Alpha-tocopherol: a natural antioxidant that reduces the formation of ROS and protects cell membranes.
Lycopene: carotene that neutralises ROS from oxidative stress. Oxidative cascade blocker.
Turmeric: source of vitamins and minerals. Prevents oxidation and provides defence against the inflammatory environment.

PREVENTS AND PROTECTS CELLULAR COMPONENTS FROM FREE RADICAL-INDUCED DAMAGE BY BOOSTING INTRACELLULAR DEFENCE MECHANISMS.

SHARPLY DECREASES INTRACELLULAR LEVELS OF ROS.

PRODUCTS ON THE MARKET

Active ingredients

WHARTON GEL COMPLEX

Cosmetic ingredient for dermo-cosmetics designed based on Histoessence technology.

REOXDERM LIQUID

Protects against oxidative stress generated by aesthetic procedures

Cosmetic ingredient for dermo-cosmetics designed on the basis of Reoxcare technology.

REOXDERM CLEANSE

Anti-acne | Antioxidant

Dermocosmetic ingredient based on Reoxcare technology.

PRODUCTS ON THE MARKET

Medical devices

HISTOESSENCE INJECTABLE

Sterile injectable mesotherapy solution designed based on Histoessence technology.

Natural glycosaminoglycans (15 mg/ml)

RESEARCH SERVICES FOR INNOVATIVE PRODUCTS

In vitro testing

CELL TYPES AND MODELS

Fibroblasts, keratinocytes, mesenchymal stem cells
Oxidative stress model
Senescence model
UV radiation exposure model

IN VITRO TESTING

Cell viability and behaviour
Protein immunolocalisation
Mitochondrial activity
Chemotactic effect
Antioxidant capacity and determination of intracellular ROS
Gene expression
Secretion of methyl-metalloproteases
Antimicrobial and antibiofilm effect

DEVELOPMENT AND MANUFACTURE OF PROFESSIONAL AND HOME-CARE PRODUCTS

Manufacturing for third parties

Cosmetic solutions for professional topical use: dermapen, microneedling, ...

Sterile medical devices for injectable use: mesotherapy, biorevitalisation, ...

Approved manufacturing facilities for medical devices and dermo-cosmetics 600 sqm

Production capacity from pilot batches to large industrial batches.