Active ingredients, medical devices and cosmetic products
Development and manufacture of effective products of natural origin for dermo-cosmetic skin and hair treatments.
Histocell presents as an ideal partner for open innovation in dermo-cosmetics.
Specialists in biotechnologies focused on regeneration and oxidative stress control applied to dermo-cosmetics.
Biotechnologies
Histocell has two proprietary technologies
Technology based on a unique natural blend of sulphated glycosaminoglycans (chondroitin sulphate, heparan sulphate, keratan sulphate and dermatan sulphate) and polydisperse hyaluronic acid.
What do these components bring?
- Recreates and regenerates the extracellular matrix
- Induces synthesis of collagen and fibronectin
- Promotes cell migration
HISTOESSENCE MIMICS THE EXTRACELLULAR MATRIX
Self-controlled industrial purification process providing extracellular matrix at different purities for a family of products (cosmetics - class III medical devices).
Technology based on an exclusive blend of natural antioxidant active ingredients.
What do these components bring?
- LBG (galactomannan): obtained from carob seed flour. Used in traditional medicine as an antioxidant and anti-inflammatory solution.
- Ascorbic acid: essential micronutrient for wound healing. Induces collagen synthesis and gives strength and resilience to new tissue.
- Alpha-tocopherol: a natural antioxidant that reduces the formation of ROS and protects cell membranes.
- Lycopene: carotene that neutralises ROS from oxidative stress. Oxidative cascade blocker.
- Turmeric: source of vitamins and minerals. Prevents oxidation and provides defence against the inflammatory environment.
PREVENTS AND PROTECTS CELLULAR COMPONENTS FROM FREE RADICAL-INDUCED DAMAGE BY BOOSTING INTRACELLULAR DEFENCE MECHANISMS.
SHARPLY DECREASES INTRACELLULAR LEVELS OF ROS.
Active ingredients
Cosmetic ingredient for dermo-cosmetics designed based on Histoessence technology.
Protects against oxidative stress generated by aesthetic procedures
Cosmetic ingredient for dermo-cosmetics designed on the basis of Reoxcare technology.
Anti-acne | Antioxidant
Dermocosmetic ingredient based on Reoxcare technology.
Medical devices
Sterile injectable mesotherapy solution designed based on Histoessence technology.
Natural glycosaminoglycans (15 mg/ml)
In vitro testing
- Fibroblasts, keratinocytes, mesenchymal stem cells
- Oxidative stress model
- Senescence model
- UV radiation exposure model
- Cell viability and behaviour
- Protein immunolocalisation
- Mitochondrial activity
- Chemotactic effect
- Antioxidant capacity and determination of intracellular ROS
- Gene expression
- Secretion of methyl-metalloproteases
- Antimicrobial and antibiofilm effect
Manufacturing for third parties
Cosmetic solutions for professional topical use: dermapen, microneedling, ...
Sterile medical devices for injectable use: mesotherapy, biorevitalisation, ...
Approved manufacturing facilities for medical devices and dermo-cosmetics 600 sqm
Production capacity from pilot batches to large industrial batches.