{"id":77197,"date":"2023-01-09T11:11:35","date_gmt":"2023-01-09T10:11:35","guid":{"rendered":"http:\/\/histocell.com\/force-repair\/"},"modified":"2023-02-24T14:19:58","modified_gmt":"2023-02-24T13:19:58","slug":"force-repair","status":"publish","type":"post","link":"https:\/\/histocell.com\/en\/force-repair\/","title":{"rendered":"FORCE REPAIR"},"content":{"rendered":"\t\t
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CURRENT PROJECTS<\/span><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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<\/span>FORCE REPAIR<\/span><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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January 2023 – December 2026<\/strong><\/p>\n

Grant agreement: 101092243<\/strong><\/p>\n

\u201cSMART AND MULTIFUNCTIONAL 4D PRINTABLE PRO-REGENERATIVE BIOLOGICAL MATRIX MODULATING MECHANOTRANSDUCTION AS ADVANCED THERAPY TO TREAT SKIN CHRONIC WOUNDS\u201d<\/strong><\/p>\n

Due to population lifestyle changes, i.e. obesity, diabetes and aging population, chronic wounds (CW) which fail to follow the typical healing process is a major medical socioeconomic challenge. Current wound management is clearly insufficient and advanced therapies failed in keeping their promise of reliable skin regeneration. The aim of FORCE REPAIR<\/strong> is to develop a smart and multifunctional wound dressing providing pro-regenerative environment and mechanical stability to treat chronic wounds (CW). Thus, FORCE REPAIR will combine state-of-the-art technologies in a biological scaffold tailored to patient\u2019s needs. A customized 3D bioprinter with a user-friendly 3D trajectory software will help to strategically placed the biological compounds to timely address and mitigate the degenerative process occurring in CW, i.e. infection, inflammation, tension forces to promote skin regeneration.<\/p>\n

The 3D printed dressing will be tested in relevant in vitro model with a human exudate library and testing relevant key healing steps (i.e. re-epithelization, angiogenesis, cell proliferation\u2026). Selected candidates will be tested in vivo on pig CW models and mice with bacterial infection. To ensure translation to clinical practice and reach patients, regulatory framework, HTA and a business model will be defined for a viable exploitation strategy that will decrease economic burden of wound care management and improve patients\u2019 QoL. Finally, to ensure market acceptance health professional will guide the development of FORCE REPAIR to offer a dressing that treat efficiently CW and can be used by medical staff.<\/p>\n

FORCE REPAIR will be executed by a consortium of 14 different partners from 8 EU Member States, carefully selected to put together a state-of-the-art advanced therapies and technologies, with the necessary knowledge in biological, cellular and immunology mechanisms, biomaterials design, 3D additive manufacturing, digitalization, regulation and business.<\/p>\n

Histocell will contribute to FORCE-REPAIR with the proprietary biomaterial Wharton Gel Complex (WGC) and its knowledge in the development of 3D printable bioinks based on WGC-HA as well as with its understanding of wound care market.<\/p>\n

Project website: www.forcerepair-wounds.eu<\/a><\/p>\n

LinkedIn: https:\/\/www.linkedin.com\/showcase\/force-repair-wounds<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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CURRENT PROJECTS FORCE REPAIR January 2023 – December 2026 Grant agreement: 101092243 \u201cSMART AND MULTIFUNCTIONAL 4D PRINTABLE PRO-REGENERATIVE BIOLOGICAL MATRIX MODULATING MECHANOTRANSDUCTION AS ADVANCED THERAPY TO TREAT SKIN CHRONIC WOUNDS\u201d Due to population lifestyle changes, i.e. obesity, diabetes and aging population, chronic wounds (CW) which fail to follow the typical healing process is a major […]<\/p>\n","protected":false},"author":1,"featured_media":78555,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-77197","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current-projects"],"_links":{"self":[{"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/posts\/77197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/comments?post=77197"}],"version-history":[{"count":3,"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/posts\/77197\/revisions"}],"predecessor-version":[{"id":77200,"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/posts\/77197\/revisions\/77200"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/media\/78555"}],"wp:attachment":[{"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/media?parent=77197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/categories?post=77197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/histocell.com\/en\/wp-json\/wp\/v2\/tags?post=77197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}