Call identifier: HAZITEK 2018-2019Reference Nº : ZL-2018/00961 y ZL-2019/00011
Action co-financed by the Basque Government and the European Union through the European Regional Development Fund 2014-2020 (ERDF).
The idea of the REPHAIR project consists of the development of a product based on a natural extracellular matrix for the restoration of hair follicles in cases of alopecia. The ultimate objective is to provide a non-surgical or minimally invasive alternative to patients. The active principle is called Native Whartonide and from it is proposed the development of the new product for the restoration of hair follicles. This principle is protected by patent (WO 2011/120535 "New Biomaterial From Wharton's Jelly Umbilical Cord") currently granted in Europe , Mexico, Japan, Australia, China, Canada and Korea.
In most alopecia, the hair follicles have not been destroyed, they remain alive and hence, in theory, their recovery is possible. Due to the role that the extracellular matrix plays in maintaining the good condition of the hair follicle and in the hair growth cycle, it is suggested that the administration of molecules such as hyaluronic acid and sulfated glycosaminoglycans could be useful to counteract the effects of alopecia. For this reason, the use of natural factors to stimulate hair growth through the application of substitutes of extracellular matrix is a great innovation in the sector.
The new product, developed within the framework of the REPHAIR project, will be a natural and safe treatment that will maintain the vitality of the scalp, slowing its loss and weakening and optimizing the growth of new hair. Thanks to its composition in glycosaminoglycans, the product will protect the hair follicles from free radicals and external aggressions, restore their hydration and create a healthy environment for hair transplantation. The new product will be applied in cases of hair transplantation, where it would help optimal treatment and healing in the donor and recipient areas. It will be implemented in hair not subjected to transplantation as well, where the product could improve the nutritional status of the follicle microenvironment, its survival rate and cell viability and, therefore, a more efficient capillary coverage.