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NEURIMP

NEURIMP

"Novel combination of biopolymers and manufacturing technologies for production of a peripheral nerve implant containing an internal aligned channels array"

Project number: 604450
Call Identifier: FP7-NMP.2013.2.2-1

 


This project has received funding from the European Community's Seventh Framework Programma (FP7-NMP-2013-SME-7) under grant agreement No. 604450

Peripheral nerves are basic communication structures guiding motor and sensitive information from CNS to effector or receptor units. Severe nerve injuries include axon bundles section and Schawnn cells destruction, which results in loss of motion control and sensorial perception. After the lesion, cells present in damaged nerves activate spontaneously self-regeneration programs that might facilitate further treatment. Nerve autograft is the "gold standard" surgical intervention that demands autologous tissue extraction and corresponding function loss.

The goal of the project is the validation of biomaterials structural plasticity and those compatible manufacturing technologies that will enable the generation of a tubular structure containing an intraluminal microstructure based on an array of aligned channels or fibers.

The regenerative properties of this prototype will be also validated in vivo in a sciatic nerve section animal model. This project proposal will take advantage of partners' experience in the design of medical devices composed of natural and synthetic biomaterials and in scaled-up production mechanization technologies for the generation of the most effective peripheral nerve implant.

The consortium is coordinated by TEKNIKER and scientifically leaded by Histocell whose will be involved in task related with:

  • Development of Hyaluronic Acid based biomaterials with neuroregenerative properties, to be used as fillers for the nerve conduit.
  • Definition of the design of novel tubular nerve guides containing an array of microchannels to enhance peripheral nerve regeneration efficacy.
  • In vitro analysis of biodegradability, biocompatibility and cytotoxicity of produced biomaterials and blends of these, in accordance with ISO 10993.
  • In vitro high throughput screening of biomaterials adequacy for neuroregeneration.
  • Market analysis and commercial exploitation plan design.

Consortium:

Neurimp project is composed by 8 partners with previous experience in national and EC funding projects. Research Organisations, Universities and SMEs are part of the Project consortium, with a clear orientation to obtaining results for SMEs.

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